Depopulation is a concerning trend with social and cultural implications, as well as impacts on territorial competitiveness. To address this issue in the Alpine region, APOLLO employs new approaches to enhance workers’ well-being and work-life balance. The project also improves tools that supported work during the pandemic, like remote working, considering the needs arising from demographic changes. By working within a territorial network, APOLLO creates synergies to promote community well-being and stimulate economic development in the region.