Although most of EUSALP regions developed S3/RIS based on EC requirements, R&I triple helix still focuses little on a transnational approach of strategic topics for the Alpine Region (AR) to better exploit economic opportunities. There is no strategic transnational collaborative framework on topics of specific alpine importance, e.g. Digital Divide, Climate Change, Biodiversity conservation, etc., both between Public Authorities (PA), and between academia and business sector (BS) with limited transnational R&I on such topics. The fact that policy makers, academia & BS are currently not always jointly valorizing elements of Smart Specialisation Strategies (S3), leads them to run at different paces holding back benefits for entire AR. A-RING will address the overall need to pool efforts in tackling major challenges with joint R&I approach steering EU Open Innovation paths.