The project 4STEPS is addressing the main challenge of Industry 4.0 (I4.0) as tool a towards a new, digital industrial revolution holding the promise of increased flexibility in manufacturing, mass customisation, increased speed, better quality and improved productivity and its development in supporting the RIS3 in the target regions and different sectors. SMEs in the target regions are lagging behind in the adoption of innovative tools and solutions proposed by I4.0 revolution and need to increase transnational collaboration in facing this challenge. Main project objective is to support the successful RIS3 implementation applying the I4.0 to all the industrial sectors identified by each region. The innovative elements of 4STPES will be the methodology applied based on the involvement of all the actors of the quadruple helix, thanks to a bottom up approach.